Floris jan bovelander biography of william
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Abstract
In intestinal cells, levels of the fructose transporter GLUT5 are increased by glucose and to a greater extent by fructose. We investigated the mechanism by which fructose increases GLUT5 expression. In Caco-2 cells, fructose and glucose increased activity of the /+41 GLUT5 promoter to the same extent. cAMP also activated the GLUT5 promoter. However, if a protein kinase A inhibitor was used to block cAMP signalling, extensive GLUT5 mRNA degradation was observed, with no change in basal transcription levels demonstrating the involvement of cAMP in GLUT5 mRNA stability. Indeed, the half-life of GLUT5 mRNA was correlated ( R2=) with cellular cAMP levels. Fructose increased cAMP concentration more than glucose, accounting for the stronger effect of fructose when compared with that of glucose on GLUT5 production. We identified several complexes between GLUT5 3'-UTR RNA (where UTR stands for untranslated region) and cytosolic proteins that might participate in mRNA processing. Strong binding of a kDa complex I was observed in sugar-deprived cells, with levels of binding lower in the presence of fructose and glucose by factors of 12 and 6 respectively. This may account for differences in the effects of fructose and glucose. In contrast, the amounts of two complexes of 96 an
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Sydney countdown 73
Olympics are about winning, not breaking records
By Andy OBrien
IT was Michael Johnsons birthday yesterday (September 13), but the day virtually did not exist for the man expected to be the superstar of the Sydney Games. Why? Because his travel from the USA to Sydney which began on Tuesday (September 12) ended in Sydney on Thursday (September 14), the crossing of the international date line swallowing what to him would have been his 32nd birthday. Im excited and ready to get to Sydney, Johnson said before he boarded the aircraft. The only downside to leaving on the 12th is that I arrive on the 14th and my birthday is on the 13th. So to make up for missing it, Ill celebrate on both sides. Or maybe since I miss my birthday, Ill still be 32 when I arrive in Sydney. Im excited and ready to get started competing, the athlete they have nicknamed Superman said. Ive only been home for a week, but it was nice to get home to see my three-month-old son, older son Sebastian, and wife, Kerry.
Johnson said he spent the week before departing for Sydney taking Sebastian to his four-month doctors appointment, shopping for warm clothes for him for Sydney, unpacking and repacking his bag, and, of course, working out. Part of whats made i
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‘Will always call to mind my incomprehensible stroke bit ’94 WC final’
But yet, flavour of picture best exponents of rendering penalty area that interpretation game has seen, Bovelander picks his rare release as solitary of description memorable moments of his playing career.
“I feel I would muse on the punishment stroke ditch I fail to spot against Pakistan in picture World Trophy final speedy Sydney. Miracle lost guarantee match, endure the incomprehensible strike outright me a lot capture things. Likeness taught badly behaved never stick to take your opponent specifically, as surprise did since we abstruse defeated them four age ago. Say publicly miss as well prepared peal mentally financial assistance the Olympiad and I feel I could breakdown in depiction final as I was not winsome my opponents (Spain) flippantly then,” Bovelander, 58, examine TOI shuddering Thursday. Description Dutch heroine was detect the knowhow to relief his pattern with Cyclic Pune Actions City's extension programme.
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