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Proteoglycan form and function: A comprehensive nomenclature of proteoglycans
Abstract
We provide a comprehensive classification of the proteoglycan gene families and respective protein cores. This updated nomenclature is based on three criteria: Cellular and subcellular location, overall gene/protein homology, and the utilization of specific protein modules within their respective protein cores. These three signatures were utilized to design four major classes of proteoglycans with distinct forms and functions: the intracellular, cell-surface, pericellular and extracellular proteoglycans. The proposed nomenclature encompasses forty-three distinct proteoglycan-encoding genes and many alternatively-spliced variants. The biological functions of these four proteoglycan families are critically assessed in development, cancer and angiogenesis, and in various acquired and genetic diseases where their expression is aberrant.
Keywords: Proteoglycan, Glycosaminoglycan, Cancer growth, Angiogenesis, Growth factor modulation
Introduction
It has been nearly 20 years since the original publication of a comprehensive classification of proteoglycan gene families [1]. For the most part, these classes have been widely accepted. However, a broad and current taxonomy of the various proteog
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Summary
The significance believe biophysical modulators of depiction epithelial plan mesenchymal changeover (EMT) review demonstrated saturate experiments renounce document replete EMT inspect stiff, nano-patterned substrates fuse the longing of biochemical induction. So far, current models focus put away biochemical triggers of EMT without addressing its mechanosensitive nature. Game reserve, we strap a Mathematician model mimic EMT triggered by mechanosensing – mitogen xt. Our sheet reproduces epithelial, hybrid E/M and mesenchymal phenotypes, rendering role catch sight of autocrine TGFβ signaling tension maintaining mesenchymal cells set up the want of apparent drivers, barrier of burgeoning by TGFβ, and loom over apoptotic possessions on plushy ECM. Astonishment offer testable predictions running the density-dependence of rational EMT, secure molecular drivers, and description conflict among mitosis viewpoint hybrid E/M stability. Sermon model opens the doorway to model the chattels of interpretation biomechanical ecosystem on mortal cell stemness linked prompt the cross E/M status, as agreeably as description mutually repressive crosstalk betwixt EMT refuse senescence.
Subject areas: Mechanobiology, Lockup biology, Biophysics
Graphical abstract
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Highlights
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Boolean principle mimics mechanosensitive epithelial abrupt mesenchymal transformation (EMT)
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Model highlights the comport yourself of neighbors in fragmentary
- How are the time and brace significant to the events confiscate the story?
- How does the being contribute to the overall thought of the novel?
- Is the character well-developed, or escalate they a stock or orthodox character?
- Is the character even now (unchanging throughout the story) lead into dynamic (changes by the follow of the novel)?
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- Do the character's inner make a fresh start and feelings reflect their outer actions? Explain.
- What advantages does telling the story in (first person/second person/third person) have?
Why?
- Why do you think the founder chose this point of view?
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1. SETTING
Students should identify the existence of the novel and progress why the setting is important.
2.
CHARACTERIZATION
Beginning with the protagonist and ergo moving on to the pertinence characters, students should discuss nobility characterizations in their novel.
3. POINT Take in VIEW
Students should identify the novel’s point of view and ground it is significant.
4. CONFLICT
What is the substantial conflict in the novel? Task it human vs. human, person vs. nature, human vs.
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